Pepperidge Farms is a bakery known for their Milano cookies, Goldfish crackers and more that are found in grocery stores across the country. The pepperidge farms remembers are from a series of commercials that uses that line usually referring to a time when things were more common back in the day. The memes use an image from Family Guy showing him holding a bag of Milanos.
The jokes and memes are similar to the commercials by referring to a time years ago like hangovers improved over time and didn't get worse, when cell phones didn't have auto correct and when there were no thots. You will find jokes like these on this page and more that remind you of s simpler time when life seemed better and easier.